Life is controlled by a milieu of macromolecular interactions. We focus on understanding structural basis for protein interactions and their applications using a variety of biophysical and biochemical techniques such as crystallography and solution scattering as well as standard techniques in molecular cell biology. We study proteins interactions in ubiquitin signaling, host-pathogen relationship and abiotic stress response signaling. We also develop mini-antibody based bionano sensors for both diagnostic and therapeutic purposes.
Education
(PhD) 2003 University of California, Los Angeles
Experience
2013 Jul ~ 2014 Aug Visiting Scholar, University of California, Los Angeles
2007 Mar ~ Present Assistant and Associate Professor, Department of Biological Sciences, Sungkyunkwan University
2004 Sep ~ 2007 Feb Visiting Fellow, National Institutes of Health
2003 Dec ~ 2004 Aug Postgraduate Researcher, University of California, Los Angeles
2013 Dec ~ Present Editorial Board, Biodesign Journal
Journal Articles
(2023)
Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
NATURE COMMUNICATIONS.
14,
1
(2023)
Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.
ADVANCED SCIENCE.
10,
14
(2020)
ClpL is a functionally active tetradecameric AAA plus chaperone, distinct from hexameric/dodecameric ones.
FASEB JOURNAL.
34,
11
(2020)
Blocking of the IL-33/ST2 Signaling Axis by a Single-Chain Antibody Variable Fragment (scFv) Specific to IL-33 with a Defined Epitope.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
18
(2020)
Ectopic Expression of OsPYL/RCAR7, an ABA Receptor Having Low Signaling Activity, Improves Drought Tolerance without Growth Defects in Rice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
11
(2020)
Atomic structures determined from digitally defined nanocrystalline regions.
IUCRJ.
7,
1
(2020)
Selection and functional identification of a synthetic partial ABA agonist, S7.
SCIENTIFIC REPORTS.
10,
1
(2020)
Selection and functional identification of a synthetic partial ABA agonist, S7..
SCIENTIFIC REPORTS.
10,
1
(2019)
Comprehensive survey of the VxG phi L motif of PP2Cs from Oryza sativa reveals the critical role of the fourth position in regulation of ABA responsiveness.
PLANT MOLECULAR BIOLOGY.
101,
4-5
(2019)
Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase, from Streptococcus Pneumoniae.
CRYSTALS.
9,
11
(2019)
Structural determinants for pyrabactin recognition in ABA receptors in Oryza sativa.
PLANT MOLECULAR BIOLOGY.
100,
3
(2019)
Two Clade A Phosphatase 2Cs Expressed in Guard Cells Physically Interact With Abscisic Acid Signaling Components to Induce Stomatal Closure in Rice.
RICE.
12,
1
(2019)
Antibody reformatting vector system (AbVec): a platform for converting single-chain variable fragment format to other ones using shared restriction enzyme sites.
Biodesign.
7,
1
(2018)
Sequence preference and structural heterogeneity of BZ junctions.
NUCLEIC ACIDS RESEARCH.
46,
19
(2018)
Induction of the pneumococcal vncRS operon by lactoferrin is essential for pneumonia.
VIRULENCE.
9,
1
(2018)
Molecular characterization of single-chain antibody variable fragments (scFv) specific to Pep27 from Streptococcus pneumoniae.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
501,
3
(2017)
Crystallization and preliminary crystallographic analysis of a zincdependent alcohol dehydrogenase from Streptococcus pneumoniae.
Biodesign.
5,
4
(2017)
Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion.
ELIFE.
6,
(2017)
Modulation of ABA Signaling by Altering VxG Phi L Motif of PP2Cs in Oryza sativa.
MOLECULAR PLANT.
10,
9
(2017)
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
NATURE CELL BIOLOGY.
19,
10
Publications
(2022)
Methods in Molecular Biology Volume 2462. Abscisic Acid
Chapter 1. Inhibition of Type 2C Protein Phosphatases by ABA Receptors in Abscisic Acid–Mediated Plant Stress Responses.
Humana.
Lead author
(2012)
Annual Plant Reviews, Volume 44, The Plant Hormone Ethylene
Chapter 7 EIN2 and EIN3 in Ethylene signaling.
Wiley.
Co-author
Patent/Intellectual Property
폐렴연쇄상구균의 Pep27에 특이적인 단일클론 항체.
19-0291-7091945.
20200519.
KOREA, REPUBLIC OF
Conference Paper
(2023)
Analysis of the interaction of DOG1 with AHG1 using size exclusion chromatography coupled small-angle X-ray scattering.
한국결정학회 정기학술대회.
KOREA, REPUBLIC OF
(2023)
A Combined Activation Mechanism of ‘Master Switch’ SLAC1.
한국구조생물학회 하계연학술대회.
KOREA, REPUBLIC OF
(2020)
Structural and biochemical studies of ClpL, an active tetradecameric AAA+ family chaperone.
제126회 대한화학회 학술발표회.
KOREA, REPUBLIC OF
(2020)
Determining Atomic Structures from Digitally Defined Regions of Nanocrystals.
American Crystallographic Association Annual Meeting.
UNITED STATES
(2020)
Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase from Streptococcus pneumoniae.
2020 한국생체분자과학연합학회 학술대회.
KOREA, REPUBLIC OF
(2020)
Effects of a hydrophobic residue in pyrabactin recognition by a rice ABA receptor.
2020 한국생체분자과학연합학회 학술대회.
KOREA, REPUBLIC OF
(2020)
Molecular details of the VxGΦL motif of PP2Cs from Oryza sativa involved in regulation of ABA responsiveness.
2020 한국생체분자과학연합학회 학술대회.
KOREA, REPUBLIC OF
(2019)
Crystallographic and computational analyses reveal that the fourth position of VxGΦL motif in type 2C protein phosphatases is critical in regulating abscisic acid signaling.
16th Conference of the Asian Crystallographic Association.
SINGAPORE
(2019)
A tryptophan residue is critical in differential pyrabactin recognition by rice ABA receptors.
제31차 방사광이용자연구발표회.
KOREA, REPUBLIC OF
(2019)
Structural and biochemical analysis of IlvC from Streptococcus pneumoniae.
2019년 한국결정학회 학술대회.
KOREA, REPUBLIC OF
(2019)
THE CRITICAL ROLE OF THE FOURTH POSITION OF THE VXGFL MOTIF OF PP2CS FROM ORYZA SATIVA IN REGULATION OF ABA RESPONSIVENESS.
32nd European Crystallographic Meeting.
AUSTRIA
(2019)
Role of a hydrophobic residue in pyrabactin recognition by ABA receptors from Oryza sativa.
2019 KSBS & SABRAO International Conferenceon Plant Breeding for Sustainable Development.
KOREA, REPUBLIC OF
(2019)
Structural basis for differential pyrabactin recognition by rice ABA receptors.
The 30th International Conference on Arabidopsis Research.
CHINA
(2018)
Structural basis for modulation of the ABA core signaling by ABA and its analogs in rice.
한국식물학회 정기학술대회.
KOREA, REPUBLIC OF
(2018)
Transgenic Approaches for Revealing function of the YxGOL Motif from OsPP2Cs in ABA Signal Transduction.
한국식물학회 정기학술대회.
KOREA, REPUBLIC OF
(2018)
Functional Analyses of the Vxcol Motif from Ospp2cs in ABA Signal Transduction.
lnternational Conference of Korean Society for
Molecular and Cellular Biology.
KOREA, REPUBLIC OF
(2018)
The change of ABA responsiveness through hydrophobic environments in the VxGΦL motif of PP2Cs in Oryza sativa.
한국육종학회-차세대BG21사업-GSP사업 공동심포지엄.
KOREA, REPUBLIC OF
(2018)
Molecular characterization of single-chain antibody variable fragments (scFv) specific to two pneumococcal antigens.
32nd Annual Symposium of the Protein Society.
UNITED STATES
(2018)
Modulation of ABA responsiveness through hydrophobic residues in the VxGΦL motif of PP2Cs in Oryza sativa.
한국구조생물학회 하계학술대회.
KOREA, REPUBLIC OF
(2018)
Selection and Characterization of Single-chain Antibody Variable Fragments (scFvs) against PspA and Pep27 from Streptococcus pneumoniae.
한국구조생물학회 하계학술대회.
KOREA, REPUBLIC OF
